Can you use a debit card to rent a vehicle?

Yes you can it will need to have a credit card logo on it, like visa or MasterCard

You could, but I highly recommend against it. Also in some states, you are required two forms of picture id plus a current a utility bill. They will also take a very large deposit. If you have a credit card, I would recommend that instead.

No

Yes, but hundreds of dollars will be withdrawn/held as security for several days past your rental return date. So it is not advised unless that's your only method of payment and you have several hundred dollars more in your debt account for them to withdraw from.

"Debit cards are not accepted at some Avis locations and are not a recommended form of prepayment."