Yes u can no problem at all.
That's one of the main reasons I always use enterprise because their one way rental is so convenient.
https://www.enterprise.com/en/help/faqs/one-way-car-rental-policy.html
I did. I picked up a car at Ft Lauderdale airport and dropped it off the next day 1 hr 45 minutes away
You can drop it off at a different location from where you originally picked up your rental. Just make sure the rental place is open the day you drop it off.
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