How is the best way to get there from JFK ?

Train to Penn Station.. Then 2 minutes walk..

Take the subway to 34St Penn Station 8th/9th

Uber or Lyft

It's better to contact the hotel's receptionist to arrange for a shuttle bus to pick you up, less stress.

Subway to Penn Station. You can walk from there in 5 to 10 minutes.

You can use a bus service, if the airport has one going to Manhattan. Ports Authority is a good stop and walking distance to the hotel. Otherwise, taxi is always an option.

Uber