Lost my Keys so only Ignition Key to Ford Focus is gone. Can I get a new Key programmed for this Ignition? Approximate Cost??

Yes about $200

Depending on the year unfortunately Ford only goes back 10 years for Key Codes because we have to look up the key code in order to cut and program another key. The vehicle would have to be present upon service visit. If the vehicle is within the perimeter of the 10 years we will need a driver license and vehicle registration or insurance card stating the vehicle belongs to you due to we have to prove ownership to Ford Motor Company for access to get the key code it.The price depends upon the year of the vehicle.

I don't know the cost but dealers are typically the only place to solve the kind of key problem. You may to bring the title with you for verification purposes.