How far is this station from LaGuardia?

Not correct. From 42nd street Port Authority station the trip to LGA is approx. 1 hour depending on how quick you are to make the transfers from train to bus. I can do it in 40 min but give yourself 1 hour or more depending on how fast you travel with luggage. At Port Authority, take the E train Queens bound service to 74th and Roosevelt stop (20-25 min). Then go upstairs and exit train station outdoors to the rear of the station where there is an Express bus to the airport Q70 bus (free transfer with metro card. Use card to obtain transfer paper ticket from the machine upstairs at the bus stop). Press button and enter your metro card and pull out paper ticket. The bus comes every 10 to 15min and takes 15 to 20 min depending on your required terminal.Good luck.

By train 2 hours, driving 45 to 65 minutes

Nicky ann is correct!!💯