No. They will be available. Only reason I would recommend reserving the tickets would be for a special event or to get discounts if offered online. Never heard of a limited supply of tickets.
Advance general admission to Middleton Place is undated and tours are scheduled upon arrival. Buying tickets in advance is not necessary, but does speed up the check-in process slightly. If you plan to visit during the busy season (April-October, especially on weekends) it is advised to arrive earlier in the day to schedule tours so you may get to experience all the tours you wish to take. As the day progresses tours may fill up and can sell out.
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