For home defense I personally load 2 #6 field loads followed by 00 buck. In normal home defense distances #6 is plenty lethal or at worst very persuasive. If it doesn't make the point the 00 buck follow up certainly will.
There are many differing opinions on this. I like to use 00 buckshot (Pros: tight grouping and increased damage. Cons: Pellets could over-penetrate), Some people like slugs (1 big bullet. Pros: very accurate and massive damage. Cons: very likely to over-penetrate) and others like using 2 shot (Very small pellets. Pros: large spread, very little chance of penetration. Cons: Large spread can hit unintended targets, minimal damage)
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