The region is hilly with abundant cliff areas, so wheelchair accessability is limited to specific areas: Ash Cave has an asphalt walkway to the cave. Conkle's Hollow Nature Preserve has a lower wheelchair accessible path. You can get a better ideas of the areas here: https://www.thehockinghills.org/hiking.htm.
The upper trail is technically accessible by wheelchair, but not the most scenic. It is also gravel, sometimes damp and steep in places. Most of the other trails are not accessible to wheelchairs at all.
Thanks! Your answer is awaiting moderation.