My wife and I will be arriving April 17th as part of the regent cruise program. Is there a rental car dropoff near the hotel and which one is nearest? Can we get transportation to the hotel from there?

Enterprise is next door. The car company that picks you up? (there quote mot mine) so should be possible

Don't know.

Hertz is the closest its literally a block away you could walk

I'm not sure if there is a nearby rental car location. We used the airport rental car center. But you can use Uber to get to where you need to be.