Is there a route from OR to CA? ( SF)

When is the next train from Portland, OR to Spokane, WA

You can use their web site to find this and to buy your tickets. I make that trip a couple of times a year. Www.amtrak.com

Yes it would be on the Coast Starlight Route

I don't work here call them if you know how to use one

Yes, look at the Coast Starlight route.

I-5 To Sacramento then 80 to San Francisco