Depends on how your budget is. There's always the W on15 and park ave. Then the moxy on 3rd Avenue and 11th street
Look for flat iron hotels which will be your best bet. However anything within an avenue or 2 is still close.
The Knickerbocker and the Lotte are two I know of. But there are others
Look for hotels in flatiron or union square.
Thanks! Your answer is awaiting moderation.