Nepenthe is located 28 miles south of Carmel on the west side of Highway 1. Detailed driving directions can be found at www.nepenthe.com . Thanks for your interest and to the rest of the Google community for helping out with answering this question. Enjoy your drive, it is one of the most beautiful in the world. As you are driving from Los Angeles, Nepenthe is 60 miles north of the Hearst Castle at San Simeon, from that point, you can expect a 1 hour and 30 minute to 1 hour and 45 minute drive, depending on traffic levels.
Nepenthe is near Big Sur. South of Carmel.
It's about 30 miles south of Carmel, in Big Sur, on HWY 1. It's about a 45-50 from Nepenthe to Carmel-by-the-Sea because of the windiness of HWY 1.
I believe that it is before Carmel.
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