Can I rent an economy car at Tampa airport (or Clearwater airport) one way to Brooksville, Florida? One way, one day...cost? I will be making frequent trips to my vacation home in Brooksville and have a car there, but will need to rent one way...

Yes, and drop car off Must have credit card. Different rates. Brooksville has 2 near Mariner/ 50 area, one on 19, 1 on County Line..main # is Reservation for ALL, so I think you set it up like that..If you travel a lot, REMEMBER A to sign up for Enterprise rewards points, goes for different levels depending how many times you use, you end up with free days, etc. Hope this helps 🤗

My guess would be yes call enterprise for prices

They have so many options that I'd say probably. Cost? No idea.