I live in the UK and doing a road trip across the U.S. over a 5 week period. Will I be able to drop the car off at J.F.K. airport?

When you book your car there is a pick up location and drop off location to choose from. Just bear in mind that there will be extra fees. Cheers

Carrentals.com. Put info in and you get the estimate charge

Why don't you call Enterprise and find out? It is more expensive to drop car off at a different location than you picked up.

I have done that before from LA to Vegas. It just means you pay more in doing that, Im from the UK. Just enter where you are picking up online and where you are dropping off and it gives you the price.