First time going and tried calling. What's the difference between House of Blues and House of Blues Restaurant? Are they one and the same or different venues/locations? If I go to the restaurant on Sat/Sun is there live music?

Same location, but different. There is a restaurant that you can go to anytime, or you can buy tickets for concerts that have nothing to do with the restaurant. I went to a concert there. To get to the doors for the area the concert was in I had to walk through the restaurant. I dont know if the restaurant has live music or not.

The restaurant and concert venue are in the same building just separated. You will have to check their website for live music on Saturday or Sunday.

Same location, music follows a schedule