Should be fine if there are no delays on your arrival
I don't like taking chances, so I leave in enough time to be an hour early.
45 minutes is very tight. I'm assuming that's landing to takeoff times, right? If so, add at LEAST 15 minutes for taxi and de-planing. That leaves you 30 minutes. If 2427 leaves from a different terminal, you won't make it. If it's the same terminal, there's a chance. If there are any delays on the origination leg, you'll never make it.
Thanks! Your answer is awaiting moderation.