It depends on when would you like to go and how far in advance are you able to book the train fare because of course the earlier you book the ride, the least expensive it would be. Also, according to Amtrak.com, there are 4 different stops in San Francisco and depending on which stop, I'm pretty sure that would effect the price also. As well as how many people are traveling with you and would you like a standard seat or sleeper room on the train? I highly recommend going to Amtrak.com to discover the true cost of travelling to San Francisco from Charleston on train. I hope this helped! :-)
Try this link: https://m.amtrak.com/h5/r/www.amtrak.com/stations/chs
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