Can I replace the original spare tire to a full size regular tire in my 2013 Prius two?

Yes you can but it will cost you more especially if you want the original rim, also you need to see if a full size tire will fit in the same space as the current spare since most spare tires are usually smaller.

My 2018 Toyota Tacoma smoke blue when start up. What causes it to smoke blue

Yeahp you can

I am sure you can but it might be more costly than else where