First, keep calling. I HAVE gotten through. I always want to speak to a live person so I don't choose the appointment line, unless that's what you want. Try not to call around lunchtime. And, finally, keep calling until you get a live person. Don't give up. I've been going there for about 15 years, so I know. Also, try to get an extension number for the party you're trying to reach (from that party) - that way, you can enter it at the appropriate time after you call and perhaps limit your time dealing with the machine or even actually reach a live person. One last thing: even after you leave a message (if you must), keep calling back.
Try the option for prescription refill.
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