I know Delta does from that airport with one layover in Atlanta Georgia
The best way to find out, well you should call Columbia Airport depending on what airline you decide to book with the layover could be more than one layover or longer hours. I use Columbia Airport because it's close to where I live and not crowded Airport. The only thing is that went up on parking. I can't leave my car it's very expensive to leave your car at the airport. Even at Charleston Airport it's ridiculous with the pandemic not gotten any better everything is still so expensive.
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