When was it ended

Mission San Luis Obispo, like all the Alta Calfornia missions along the Camino Real, were sold after the Mexican Secularization Act of 1833. The last Franciscan Father Abella died in 1842. Soon after, in 1845, the Mexican Governor Pio Pico sold all the Mission's assets (except the church itself) for $510.00. In 1846, the United States Army used the church as a base of operations during the Mexican-American War. After the war, priests rented rooms in hopes of keeping the Mission open. But it soon fell into disrepair. The church temporarily became the county's first courthouse and jail. With the Mission's 100th Anniversary in 1872, improvements were started. But it wasn't until 1933 that interest in saving historic Mission San Luis Obispo became serious, bringing the Mission back to its original architectural structure. It currently serves as an active Roman Catholic parish. One could say this Mission never really "ended." Like all of the missions, it's had a complicated history.

When was what ended?

I don't understand your question. But the mission has not ended. They still hold services in the church there and have tours of original mission.