They accept donations any time they are open.
They do take large donations, but they usually don't have staff to help unload because they aren't very busy. You'll need to be able to unload it and bring it inside. It's worthwhile in my opinion though because they will resell it at a reasonable price.
They take almost everything don't hesitate to give them a call
This is mostly a thrift store for clothing. I went there at 11 am and they were open to accept donations.
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