Betty, I would have to agree with Robert- probably two hours, due to all the I-4 construction. Sanford is just outside of Orlando to the north, and it's easy to find getting off of I-4. It's very enjoyable, and reccomend it even though it will take a little time to get there!
I would Google it not sure where in Tampa you're located.
Depending on the traffic on interstate 4 up to 2 hours... 😵
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