The best place to park for handicap accessibility is the Innovation Parking Garage. There are two elevators - labelled as "Elevator to The Theater" which will take you directly to either the box office (1st floor) or auditorium (2nd floor).
It depends on the type of handicap. You can try to find a spot on the street. There's a small parking lot across the street located at tower 280. And then there is a very large underground parking garage (midtown parking garage). The entrance for that is on south Clinton. And they have elevator's.
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