Is there a bus that goes to Tupelo, Mississippi, from Fort Wayne?

Yes there is a bus station there. Greyhound has a great site that you can input where you are and where you want to go and it will show you the schedules. I'm guessing it will take 24 hours at least to get there if not longer. Good luck with your trip.

I have no idea, sorry. GPS 👍

Not sure would have to call them to find out.

Try calling & asking

Call the bus station