Week days are cheaper and yes
Tuesday through Thursday is cheapest. No, buying round trip, in most cases you are "locked in" on the return trip, and it gets expensive to change dates... A like trick, in case you aren't in a hurry: First, buy online; Second, buy as you go... For instance, going from Miami to NY, you'll change buses about 6 times... Buy the tickets based on Transfer point to Transfer point, it gets cheaper, especially if a weekend is involved!
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