Yes. The park isn't flat but there are sidewalks. You may want to enter from the higher side if you want to overlook the park without having to go up a steep hill.
Dolores Park is wheelchair accessible but I can't guarantee how safe it will be to actually use the wheelchair there. There are paved sidewalks but a lot of steep hills.
+1 to the above answer
The park is on a hill but it's pretty flat once you're there. I wouldn't try push up the hill to get there though.
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