Home Depot on Jefferson is accessible from the Jefferson blvd I 405 exit, and also from Lincloln blvd northbound or southbound. The 405 and Lincoln are bad at rush hour -- but the store is open late (i think 10 but check my facts!)
Agree with Raj. And it's open until 11 afaik.
All depends on where live, but Blake Sloan is right. Just remember that at rush hour every street is bad. Just go to that store around 7pm, it will be easier and faster to get there.
If you mean to the store, avoid Lincoln. Centinela to Jefferson probably, depending on the time of day
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